Using randomization tests to preserve type I error with response adaptive and covariate adaptive randomization
نویسندگان
چکیده
منابع مشابه
Using Randomization Tests to Preserve Type I Error With Response-Adaptive and Covariate-Adaptive Randomization.
We demonstrate that clinical trials using response adaptive randomized treatment assignment rules are subject to substantial bias if there are time trends in unknown prognostic factors and standard methods of analysis are used. We develop a general class of randomization tests based on generating the null distribution of a general test statistic by repeating the adaptive randomized treatment as...
متن کاملAdaptive Randomization Using PROC MCMC
Based on work by Thall et al. (2012), we implemented a Bayesian method for randomizing patients in a Phase II trial. According to this method, each patient is rated for efficacy and toxicity levels at a specified time point after being randomized to a dose. Evidence is accumulated that identifies which dose(s) of a cancer treatment provide the most desirable profile, per a utility score matrix ...
متن کاملAdaptive randomization procedures for the web-based randomization system RANDI2.
©2012 Dustri-Verlag Dr. K. Feistle ISSN 0946-1965 DOI 10.5414/CPP50085 e-pub: December 28, 2011
متن کاملCan response-adaptive randomization increase participation in acute stroke trials?
BACKGROUND AND PURPOSE A response-adaptive randomization (RAR) trial design actively adjusts the ratio of participants assigned to each trial arm, favoring the better performing treatment by using outcome data from participants already in the trial. Compared with a standard clinical trial, an RAR study design has the potential to improve patient participation in acute stroke trials. METHODS T...
متن کاملA Graphical Method for Comparing Response-Adaptive Randomization Procedures
Abstract Response-adaptive randomization procedures have a dual goal of estimating the treatment effect and randomizing patients with a higher probability of receiving the superior treatment. These are competing objectives, and no procedure in the literature is “perfect” with respect to both objectives. For clinical trials of two treatments, we discuss metrics for comparing response-adaptive ra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Statistics & Probability Letters
سال: 2011
ISSN: 0167-7152
DOI: 10.1016/j.spl.2010.12.018